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Our Expertise

Mastering Polynucleotides since 1952

The power of regeneration unlocked by a relentless passion for science and innovation

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Our Science
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Mastelli World

Since our beginnings, we have embraced the potential of Polynucleotides—organic molecules that activate the body’s natural ability to regenerate.

Born as a small laboratory, we have always maintained full control over our production chain and invested in an internal research and development center, supporting responsible medicine with the passion and integrity that define us.

Bio-regeneration is the foundation of our approach: it hydrates and supports the natural ability of the skin to restore balance, elasticity, helping to improve tone, firmness, and radiance


Discover our complete portfolio

Plinest Gallery 1
Face
Plinest

Plinest is a sterile, single-use, viscoelastic gel with polynucleotides for intradermal use. It helps provide hydration and support to the skin in case of skin elasticity, firmness and tone loss. These effects can also favour the remodelling of areas with a strong fibrous component.

Plinest is indicated for the treatment of younger skin and acne scars

Newest Gallery 2
Face, Décolleté, Neck
Newest

Newest is a sterile, single-use viscoelastic gel for intradermal use, with polynucleotides and hyaluronic acid. Polynucleotides HPT® and Hyaluronic Acid provide deep hydration and enhance elasticity, counteracting skin aging in case of firmness and tone loss

Newest is indicated for dehydrated and mature skin

Plinest Eye Gallery 1
Eye contour
Plinest Eye

Plinest Eye is a sterile, single-use, viscoelastic gel with polynucleotides for intradermal use, indicated for the periocular area. It helps provide hydration and support to the skin in case of skin elasticity, firmness and tone loss.

Plinest Eye is indicated for delicate areas, such as the eye contour

Plinest Hair Gallery 1
Hair and eyebrows
Plinest Hair

Plinest Hair is a sterile, single-use, viscoelastic gel with polynucleotides for intradermal use. Treatments with Plinest Hair in areas with a high fibrous content and signs of atrophy help to promote the exchange of water to restore skin function.

Being versatile and easy to handle, Plinest Hair can be used on eyebrows and the scalp. If the hair follicle is not completely atrophied, it is possible to use Plinest Hair as an adjuvant to treat thinning hair

Plinest Fast Gallery 1
Sensitive areas
Plinest Fast

Plinest Fast is a sterile, single-use, viscoelastic gel with polynucleotides for intradermal use. Treatments with Plinest Fast in areas with a high fibrous content and signs of atrophy help to promote the exchange of water to restore skin function.

Thanks to its versatility and ease of use, Plinest Fast can be used in any area of the skin, particularly in the sensitive, delicate areas

Plinest One Gallery 1
Extended Areas
Plinest One

Plinest One is a sterile fluid gel based on polynucleotides for intradermal use. It is indicated to improve the firmness, elasticity, and tone of the skin all over the body and to promote the remodelling of areas with a high fibrous component, such as striae and depressed scar outcomes.

Plinest One is indicated for the treatment of large body areas, such as the abdomen, buttocks, thighs, and arms

Newest One Gallery 1
Extended Areas
Newest One

Newest One is a sterile fluid gel containing polynucleotides and hyaluronic acid for intradermal use. Polynucleotides and Hyaluronic Acid provide deep hydration, improve turgor, elasticity and tone of the body, and promote the remodelling of high fibrous content areas, such as striae and depressed scars

Newest is indicated for extended areas treatment, such as the abdomen, buttocks, arms, thighs

Newgyn Gallery 1
Genital areas
NewGyn

NewGyn is a sterile, single-use viscoelastic gel for intradermal and/or intramucosal use, with polynucleotides and hyaluronic acid. Polynucleotides and Hyaluronic Acid provide deep hydration and improve turgidity, as well as restore the physiological function of the superficial layers of the skin and mucous membrane in the genital area

NewGyn helps to counteract dehydration related symptoms, such as dryness, irritation, itching, and dyspareunia in the genital area

Ialest Gallery 1
Face
Ialest

Ialest is a sterile, single-use, viscoelastic gel with biotechnological hyaluronic acid. Hyaluronic acid is essential for skin structure and elasticity and helps combat free radicals.

Ialest is indicated for deep hydration and treatment of depressed scars (acne and chickenpox scars)

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Skin Priming

Skin Priming

The "PN HPT® Priming" concept is all about harnessing the power of PN HPT® to amplify and accelerate the skin's response to subsequent revitalization treatments.

PN HPT® is the definitive pre-treatment solution, priming tissues to achieve unparalleled aesthetic results when integrated with other therapies.

This innovative approach significantly enhances the efficacy of various procedures, from wound care to dermatology and aesthetic medicine, establishing a bold new benchmark for superior, lasting outcomes.

Supported by evidence-based research, experts widely recognize the synergistic benefits of PN HPT® when combined with treatments such as lasers, energy-based devices, fillers, peels, microneedling, and even surgical procedures

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