Mastelli, an Italian Bio-Pharmaceutical family-owned company, has been proudly based in the scenic Italian Riviera town of Sanremo since 1952.
The company is globally recognized for pioneering research and development of Highly Purified Polynucleotides (PN HPT®), a complete portfolio covering many therapeutic areas, from aesthetics to orthopedics.
With a legacy built over three generations, the company is steadfast in its mission to lead the science and innovation of Bio-Regeneration.
Recently, Mastelli has embarked on an exciting phase of expansion, venturing Polynucleotides' potential in more than 40 countries worldwide.
Mastelli in aesthetic medicine offers advanced treatments that provide clinical benefits such as biostimulation, cellular regeneration, and skin rejuvenation. These solutions are applied to various areas, particularly the face and the delicate eye contour, helping to refresh the gaze and improve overall skin quality.
At the core of these treatments are Polynucleotides. PN HPT® (Polynucleotides High Purification Technology), developed by Mastelli, are highly purified and biocompatible polynucleotides capable of stimulating the skin’s natural regenerative processes and collagen production, while promoting deep tissue hydration
Mastelli addresses musculoskeletal disorders such as osteoarthritis (joint degeneration), tendinitis, and other degenerative or post-traumatic joint conditions, which often cause pain and restricted movement. The company develops safe and innovative therapeutic solutions based on natural-origin raw materials and proprietary technologies: Polynucleotides High Purification Technology (PN HPT®).
These molecules, composed of DNA fragments extracted using advanced purification techniques, stimulate the repair processes of damaged tissues, promoting the regeneration of cartilage and tendons. Through targeted infiltrations, polynucleotide-based treatments initially act as a lubricating and protective cushion within the joint, then gradually release nutrients that support the natural reparative processes of cartilage and other tissues.
These treatments have been shown to significantly reduce pain, improve joint function and mobility, and enhance patients’ quality of life
Wound care includes all treatments and measures that help wounds heal properly, whether they are acute (such as cuts or surgical wounds) or chronic and difficult to heal (such as skin ulcers, pressure sores, or burns). The use of advanced therapies in this field is essential to promote faster and more effective healing, reduce the risk of infections and complications, and improve patients' quality of life.
Mastelli is strongly committed to this therapeutic area, developing innovative solutions based on biocompatible components and cutting-edge technologies, thanks to Polynucleotides (PN) and Polydeoxyribonucleotides (PDRN). These advanced treatments support the body’s natural tissue regeneration process, offering patients safe and innovative care for optimal healing
Dermatology is the medical field that focuses on skin health, our body’s largest organ and a vital protective barrier. Conditions such as dryness, irritation, dermatitis, acne, or skin aging can affect overall well-being and daily quality of life. That’s why proper and effective skin care is essential.
Mastelli is deeply committed to dermatology, offering advanced, well-tolerated solutions designed to meet the needs of all skin types, including sensitive skin. Through its research on Polynucleotides (PN) and Polydeoxyribonucleotides (PDRN), the company develops innovative products that support skin regeneration, improve hydration, and help reduce signs of aging, promoting healthier, more resilient, and visibly revitalized skin
Gynecology is the medical field dedicated to the health of the female reproductive system at every stage of life, from the fertile years through menopause and beyond. Conditions such as dryness, irritation, inflammation, or imbalances in the vaginal microbiota can impact daily comfort and intimate well-being. Mastelli supports women with safe, gentle, and innovative solutions tailored to the specific needs of the vulvovaginal ecosystem.
Through research on Polynucleotides (PN) and Polydeoxyribonucleotides (PDRN), the company develops treatments that help restore tissue integrity, enhance hydration, and support the body’s natural regenerative capacity, offering effective and respectful care for lasting comfort and protection
Mastelli is committed to dentistry to improve and protect patients’ oral health. Through innovative Polynucleotides HPT®-based solutions, the company supports gum tissue regeneration following dental procedures. Each treatment is designed to be both effective and gentle, while also helping to maintain the balance of the oral microbiota—the community of beneficial bacteria that naturally protects the mouth and gums
The Mastelli dermocosmetic line is rooted in bioregeneration expertise and research on nucleotides, organic molecules that support the skin’s natural repair and renewal processes. Formulated to provide deep hydration, elasticity, and radiance, Mastelli cosmetics are ideal for reducing the signs of aging, soothing sensitive skin, and preserving the skin’s natural balance. An advanced skincare line, scientifically developed for the daily well-being of your skin
With over 70 years of expertise in developing PDRN (Polydeoxyribonucleotide)-based drugs, Mastelli leverages this DNA-derived technology’s proven ability to promote tissue repair and regeneration. This enduring commitment to scientific excellence continues to drive Mastelli’s development of advanced regenerative therapies, reaffirming its leadership in the pharmaceutical sector
In 2005, the third Mastelli generation, always working closely with the scientific community, discovered a new molecule, Polynucleotides, and turned it into a game-changer worldwide, from aesthetics to orthopedics